Regulatory T cells but not NKT I cells are modulated by a single low-dose cyclophosphamide in a B cell lymphoma tumor-model

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dc.contributor.author Rico, María José
dc.contributor.author Rozados, Viviana R.
dc.contributor.author Mainetti, Leandro Ernesto
dc.contributor.author Zacarías Fluck, Mariano
dc.contributor.author Matar, Pablo
dc.contributor.author Scharovsky, O. Graciela
dc.date.accessioned 2012-08-24T14:59:09Z
dc.date.available 2012-08-24T14:59:09Z
dc.date.issued 2012-03
dc.identifier.issn 1812-9269
dc.identifier.uri http://hdl.handle.net/2133/2006
dc.description.abstract Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell populations of the innate immune response with opposing effects on the tumors, in a rat B cell lymphoma model. Methods: Inbred e rats were challenged s.c. with L-TACB lymphoma and on day 14 animals were distributed in two groups. Treated: injected i.p. with cyclophosphamide (10mg/kg of body weight) and Control: injected i.p. with saline. Blood samples were taken from days 0 to 21 and the percentage of T regulatory and natural killer T I cells were determined by flow cytometry. Results: We found that the increase of natural and inducible T regulatory cells of peripheral blood achieved during tumor growth was significantly downregulated by cyclophosphamide. On the contrary, natural killer T I cells were not modulated by the treatment. Conclusion: The antimetastatic effect of a single low dose of Cy would be due, at least in part, to downregulation of natural and inducible T regulatory cells. es
dc.description.sponsorship Cibic S.A. This work was supported by a grant from Universidad Nacional de Rosario to O.G. Scharovsky. es
dc.format application/pdf
dc.language.iso en es
dc.publisher MORION LLC es
dc.rights openAccess
dc.subject T regulatory cells es
dc.subject NKT I cells es
dc.subject cyclophosphamide es
dc.subject lymphoma es
dc.subject.mesh Animals
dc.subject.mesh Antineoplastic Agents, Alkylating/administration & dosage
dc.subject.mesh Cyclophosphamide/administration & dosage
dc.subject.mesh Disease Models, Animal
dc.subject.mesh Female
dc.subject.mesh Lymphoma, B-Cell/drug therapy
dc.subject.mesh Lymphoma, B-Cell/immunology
dc.subject.mesh Natural Killer T-Cells/immunology
dc.subject.mesh Rats
dc.subject.mesh T-Lymphocytes, Regulatory/drug effects
dc.subject.mesh T-Lymphocytes, Regulatory/immunology
dc.title Regulatory T cells but not NKT I cells are modulated by a single low-dose cyclophosphamide in a B cell lymphoma tumor-model es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.description.peerreviewed Peer reviewed es
dc.rights.text © Experimental Oncology, 2012 es


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